The search for mesenchymal stem cells with tissue-specific engraftment potential

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670106
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Yuba Shunsuke 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 研究グループ長 (40263248)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 幹細胞 / 組織

Outline of Final Research Achievements

From experience that went intravenous systemic transplantation of bone marrow mesenchymal stem cell (MSC) in clinical studies, we thought that trying to clear whether the cells that efficiently engraft to the specific tissue are present in the nonhomogeneous MSC. Firstly, we collected the fluorescence-labeled MSC from bone marrow of rats with systemic expressing GFP and transplanted cultured MSC into another rats systemically. The single cell suspensions from various organs of the transplanted rat were obtained without damaging the cells in use of the tissue dissociator. We are going to decide to whether the MSC derived from various organs can be engrafted in target organs from now on. If these cell populations exist, the purification method development and clinical application would come into the field of view.

Free Research Field

再生医療