Profiling of Central Arterial Hemodynamics for Cerebrovscular Disease Prevention

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670116
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: Sugawara Jun 国立研究開発法人産業技術総合研究所, 人間情報研究部門, 主任研究員 (00357261)
• Co-Investigator(Renkei-kenkyūsha): MAEDA Seiji 筑波大学, 体育系, 教授 (30282346)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 脳血管疾患 / 加齢 / 動脈伸展性 / 有酸素性持久力 / 周波数解析

Outline of Final Research Achievements

From the standpoint of cerebrovascular diseases prevention, we sought useful assessment for pulsatility of cerebral hemodynamics by frequency-domain analysis in 14 healthy young men (Study 1), and elucidate physiological mechanisms responsible for carotid arterial distensibility in healthy men with wide age-range (18-64 yrs) (Study 2). In Study 1, pulsatile component of transfer function gain (between pulsatile aortic pressure and pulsatile cerebral blood flow velocity) was significantly enhanced by -30 mmHg of lower-body negative pressure, suggesting that moderate sympathetic nervous stimulation can manipulate pulsatile component of hemodynamic transmission. Results of Study 2 show that greater gradient of blood flow velocity during a cardiac cycle are favorably associated with distensibility of carotid artery, and that greater gradient of blood flow velocity is associated with higher aerobic capacity (e.g., maximal oxygen consumption).

Free Research Field

循環生理学