2016 Fiscal Year Final Research Report
A research on the effects of miRNAs on serotonergic neuronal functions
| Project/Area Number |
26670122
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
NAGAYASU Kazuki 京都大学, 大学院薬学研究科, 助教 (00717902)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | セロトニン / miRNA / 幹細胞 |
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| Outline of Final Research Achievements |
The understanding of biological mechanisms for psychiatric disorders is important for the development of new therapeutic strategy. Here we focused on the miRNAs highly expressed in serotonergic neurons, one of the most important neurons in mood regulation and hallucination. As a result, we found that (1) in immature brain, a certain miRNA affects the expression level of transcription factors important for normal development of serotonergic neurons and a certain type of serotonin receptor and that (2) in mature brain, a certain miRNA affects the expression level of transcription factors important for normal function of serotonergic neurons and serotonin metabolism.
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| Free Research Field |
神経薬理学
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