Elucidation of a new differentiation mechanism of beige adipocytes and its application for drug design

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670124
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Kobe University
• Principal Investigator: SAITO NAOAKI 神戸大学, バイオシグナル研究センター, 教授 (60178499)
• Co-Investigator(Kenkyū-buntansha): UEYAMA Takehiko 神戸大学, バイオシグナル研究センター, 准教授 (80346254)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 脂肪細胞 / 分化誘導因子 / ケラチノサイト / Rac

Outline of Final Research Achievements

We studied a new Rac-medicated pathway which can induce　the differentiation of adipocytes. Using DNA microarray and RT-PCR, we found 5 factors (a,b,c,d,e) secreted from keraninocytes when Rac-mediated pathway is activated. Differentiation of adipocyte (3T3-L1 cells) was significantly enhanced when the cells were treated with the combination of a+b or a+c, much more than treated with a, b or c alone. We further elucidate whether the signal induces the diffentiation to white or beige adipocyte and we study the new drug target for the disorder of lipid/glucose metabolim.

Free Research Field

薬理学