2015 Fiscal Year Final Research Report
Calcium signal as a potential clinical target for breast cancer
| Project/Area Number |
26670125
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 受容体・チャネル / シグナル情報伝達系 / カルシウム |
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| Outline of Final Research Achievements |
To elucidate the function of calcium signaling in the mammary gland, we have analyzed the role of store-operated calcium entry in mammary epithelial cells using cell-type specific Stim1 or Stim2 or both knockout mice. We found that store-operated calcium entry is activated in mammary epithelial cells. We then established mice in which store-operated calcium entry is ablated in mammary epithelial cells. The mice normally grew up and no abnormality of the development of mammary gland, however, new-born pups nursed by female mice ablated both Stim1 and Stim2 in mammary epithelial cells showed severe growth retardation because of impaired secretion or production of milk. These results indicate that store-operated calcium entry is essential for the function of mammary epithelial cells.
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| Free Research Field |
免疫学
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