2015 Fiscal Year Final Research Report
Novel regulation of synaptic plasticity by intracellular acetylcholine receptors
| Project/Area Number |
26670129
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General pharmacology
|
|---|
| Research Institution | Kanazawa Medical University |
|---|
Principal Investigator |
KUDO Makiko 金沢医科大学, 医学部, 研究員 (50722253)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MASUOKA Takayoshi 金沢医科大学, 医学部, 講師 (80509307)
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 海馬 / アセチルコリン / 細胞内受容体 |
|---|
| Outline of Final Research Achievements |
We have reported that muscarinic acetylcholine receptors M1 (M1-mAChRs) are functionally expressed in the intracellular membranes of cortical and hippocampal neurons, and facilitate long-term potentiation (LTP) in hippocampal CA1 synapses. In this study, we clarified whether endogenous agonist acetylcholine activates the intracellular M1-mAChRs and regulates hippocampal synaptic plasticity.
|
| Free Research Field |
薬理学
|
