The role of Slp2-a in the control of renal cell size

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670149
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Kobe University (2015); Tohoku University (2014)
• Principal Investigator: YASUDA Takao 神戸大学, 医学(系)研究科(研究院), 助教 (70598482)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: Slp2-a / ezrin / 腎臓尿細管上皮細胞 / 嚢胞性腎疾患 / 慢性腎不全

Outline of Final Research Achievements

Polycystic kidney diseases (PKDs) are the most frequent genetic cause of end-stage renal disease that are characterized by renal cyst growth. Since there is still no treatment for PKDs, determining the molecular mechanisms of the pathogenesis of PKDs is crucial to the search for therapeutic targets. We found the critical involvement of synaptotagmin-like protein 2-a (Slp2-a) and its signaling in the control of renal cell size and morphogenesis by using Madin-Darby canine kidney II (MDCK II) cells and rodent models of human nephronophthisis. Modulation of the activity of Slp2-a signaling would be a novel effective treatment option for PKDs.

Free Research Field

細胞生物学