2015 Fiscal Year Final Research Report
Molecular mechanism supporting NRF2-addicted cancers
| Project/Area Number |
26670150
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 転写因子 / がん / がん遺伝子 / 酸化ストレス応答 |
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| Outline of Final Research Achievements |
NRF2 is a master transcriptional activator playing a critical role in the defense mechanism against oxidative insults. NRF2 activates genes encoding cytoprotective enzymes and antioxidant proteins in response to electrophiles and reactive oxygen species (ROS), conferring resistance against xenobiotic and oxidative stress. While NRF2 activation is beneficial to our health, NRF2 is responsible for the malignant progression of various human cancers. Inhibition of NRF2 activity is considered to be effective for the regression of tumors, but it also gives disadvantage to cancer-bearing hosts by reducing the anti-cancer immunity and stress response ability. In this study, we have established a screening system for the exploration of synthetic lethal factors with NRF2 in cancer cells.
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| Free Research Field |
生化学・分子生物学
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