2016 Fiscal Year Final Research Report
Identification of activator of glucose-stimulated insulin secretion by high-throughput chemical screening
| Project/Area Number |
26670151
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | インスリン / 糖尿病 / ケミカルバイオロジー |
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| Outline of Final Research Achievements |
Over 400 million people had diabetes mellitus in the world, and new drug development is important for the reason. We established a high-throughput screening assay system for the identification of chemical compounds that enhance (or inhibit) insulin secretion. In consequence, we identified six effective chemicals. To investigate molecular mechanism of these chemical compound activated (or inhibited) insulin secretion, we performed comprehensive binding assay with these chemicals in INS1 832/13 cells. we identified mitochondrial protein as the one of activator of chemical. Therefore, we obtained basic data to develop a new drug for diabetes.
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| Free Research Field |
分子生物学
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