2016 Fiscal Year Final Research Report
A new approach to the treatment of asthma by the regulation of a novel subset of lymphocytes
| Project/Area Number |
26670161
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 気管支喘息 / IL-33 / 分泌型ST2 |
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| Outline of Final Research Achievements |
Natural Helper (NH) cells, referred to as type 2 innate lymphoid cells, were recently discovered as a novel target of IL-33. NH cells produce Th2 cytokines in response to IL-33 and may contribute to asthma. Soluble ST2 (sST2) consists of extracellular domain of ST2L, interleukin (IL)-33 receptor, and directly binds to IL-33 as a decoy receptor. Here, we investigated the suppressive effect of sST2 on the IL-33 function. Pretreatment of sST2 reduced effectively IL-33-induced responses in lung NH cells. In asthma model mice, intranasal administration of sST2 attenuated airway inflammation. These results indicate that sST2 suppresses the IL-33-induced allergic reaction via lung NH cells in vitro and in vivo.
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| Free Research Field |
生化学
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