Identification of the specific metabolic system for cellular senescence and tumorigenesis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670163
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pathological medical chemistry
• Research Institution: Kyushu University (2016); Keio University (2014-2015)
• Principal Investigator: Minamishima Yoji Andrew 九州大学, 生体防御医学研究所, 特任准教授 (20593966)
• Co-Investigator(Renkei-kenkyūsha): Akiko Kubo 慶應義塾大学, 医学部, 特任講師 (50455573) ; Takako Hishiki 慶應義塾大学, 医学部, 特任講師 (10338022) ; Yuki Sugiura 慶應義塾大学, 医学部, 特任講師 (30590202)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 細胞老化 / 代謝 / 不死化 / 癌化 / 低酸素

Outline of Final Research Achievements

We have performed metabolome analysis on fresh, senescent, and immortalized stage in “cellular senescence to spontaneous immortalization model” using mouse embryonic fibroblasts (MEFs) 3T3 technique.
Several senescent stage-specific and immortalization-specific metabolic pathways were determined, and tetracycline-inducible tunable senescence / immortalization cellular model were under development.

Free Research Field

細胞内エネルギー代謝