2015 Fiscal Year Final Research Report
Molecular mechanism of DDAH2 associated stromal formation in lung adenocarcinoma
| Project/Area Number |
26670172
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | DDAH2 |
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| Outline of Final Research Achievements |
We examined the functional significance of DDAN2 expression in the stroma of the lung adenocarcinoma. Using immunohistochemistry, we examined expression of DDAH2. Interestingly, almost all cases of MIA and invasive adenocarcinoma were positive for DDAH2, while only half of pre-invasive lesions were positive. High expression of DDAH2 was significantly associated with poor outcome (p<0.026). Expression of both DDAH2 and eNOS by western blotting showed both to be expressed at a significantly higher level in invasive adenocarcinoma than in AIS and normal lung. DDAH2 is expressed in carcinoma-associated fibroblast and might play an important role in tumor invasion by promoting tumor angiogenesiss through an increase of NO production.
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| Free Research Field |
診断病理学
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