Role of Non-coding RNA of T-UCR in exosome in diagnosis and therapy of gastric and prostatic cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670175
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Hiroshima University
• Principal Investigator: YASUI WATARU 広島大学, 医歯薬保健学研究院, 教授 (40191118)
• Co-Investigator(Renkei-kenkyūsha): OUE NAOHIDE 広島大学, 大学院医歯薬保健学研究院, 准教授 (60346484)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: エクソソーム / ncRNA / 超保存領域（T-UCR） / 胃癌 / 前立腺癌 / 診断・治療展開

Outline of Final Research Achievements

By the analysis of Transcribed ultraconserved region (T-UCR) transcripts, the levels of many T-UCRs are found to be altered in cancers. Among those, Uc.416+A,up-regulated in cancer, was negatively regulated by miR-153 and participated in cell growth through IGFBP6 and HOXB5/B6. Uc.416+A was secreted from cancer cells and high levels were detected in the sera of cancer patients. Application to liquid biopsy system is expected.

Free Research Field

医歯薬学