Investigating the mechanisms of regulatory T cell expansion by aging

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670192
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Nagoya City University
• Principal Investigator: Yamazaki Sayuri 名古屋市立大学, 医学(系)研究科(研究院), 教授 (70567255)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 制御性T細胞 / 樹状細胞 / 加齢 / 免疫抑制

Outline of Final Research Achievements

Immune suppression in aging contributes to developing serious infection and cancer. To improve the immune suppression in aged population and contribute to expand healthy aged people, we invested the mechanisms how regulatory T cells are increased in aging using aged mice. We found that a special subset of regulatory T cells that increased in aged mice (Yamazaki et al, manuscript in preparation), and the research is ongoing currently.

Free Research Field

免疫学