2015 Fiscal Year Final Research Report
Comprehensive mitochondrial quality control and its collapse in metabolic diseases
Project/Area Number |
26670193
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
|
Research Institution | Tokyo University of Science |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SUDO Yuka 東京理科大学, 薬学部, 助教 (70646695)
OKITA Naoyuki 公益財団法人佐々木研究所, 付属研究所, 研究員 (60453841)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Keywords | カロリー制限 / ミトコンドリア / 品質管理 / シグナルペプチダーゼ / Sirt3 / Mipep / ノックアウトマウス |
Outline of Final Research Achievements |
We discovered that the activation of Sirt3 processing plays an important role of the improvement of mitochondrial (MT) quality control by anti-aging and prolongevity actions of calorie restriction. In the processing of the MT protein, MT signal peptidases are involved. We found that two signal peptidases, MPP and Mipep, were involved in the processing of Sirt3 protein. In addition, CR upregulated the expression of Mipep but not MPP. Therefore, we considered Mipep is important to the improvement of CR-associated MT quality control. In order to prove in vivo, the organ-specific Mipep-deficient mice were created. In the future, we are going to analyze these mice.
|
Free Research Field |
実験病理学
|