Elucidation of malaria invasion mechanism into erythrocyte by reverse chemical genetics

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670202
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Parasitology (including sanitary zoology)
• Research Institution: Ehime University
• Principal Investigator: Tsuboi Takafumi 愛媛大学, プロテオサイエンスセンター, 教授 (00188616)
• Co-Investigator(Kenkyū-buntansha): TAKASHIMA Eizo 愛媛大学, プロテオサイエンスセンター, 准教授 (50366762)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: マラリア / リバースケミカルジェネティクス / 赤血球侵入

Outline of Final Research Achievements

To develop a novel approach, reverse chemical genetics, for elucidation of malaria invasion mechanism into erythrocyte, we first identified a molecular-molecular interaction between malaria parasite proteins, GAMA and MSP10. We then successfully established a high-throughput screening system for inhibitors which will inhibit GAMA-MSP10 interaction by applying AlphaScreen technology. This screening system would be useful to discover not only novel malaria drug candidates but also elucidation of molecular mechanism of erythrocyte invasion of the parasite.

Free Research Field

寄生虫学