Defense mechanism of Amoebal endosymbiont Neochlamydia on host defense against harmful Legionella infection

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670206
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Hokkaido University
• Principal Investigator: Yamaguchi Hiroyuki 北海道大学, 保健科学研究院, 教授 (40221650)
• Co-Investigator(Kenkyū-buntansha): MATSUO Junji 北海道大学, 大学院保健科学研究院, 講師 (50359486) ; NAKAMURA Shinji 順天堂大学, 医学研究科, 助教 (40207882) ; HAGA Sanae 北海道大学, 大学院保健科学研究院, 博士研究員 (60706505)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 共生 / 原始的なクラミジア / アメーバ

Outline of Final Research Achievements

Previous our work has shown that obligate intracellular amoebal endosymbiont Neochlamydia has a critical role into host amoebal defense against harmful Legionella infection, causing amoebal killing. Here, to clarify the defense mechanism, we found a crucial piece that amoebal endosymbiotic Neochlamydia specifically could sense Legionella T4ASS (Lvh), but not T4BSS (Dot/Icm), presumably connecting to the host defense against harmful Legionella infection.

Free Research Field

細菌学