Establishment of absolute anaerobic biology for pathogenic evaluation of EHEC

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670208
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Bacteriology (including mycology)
• Research Institution: Chiba University
• Principal Investigator: Shimizu Takeshi 千葉大学, 大学院医学研究院, 准教授 (70312840)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 腸管出血性大腸菌 / 志賀毒素 / 嫌気状態 / 活性酸素種 / 増殖性 / 病原性 / 抗菌薬

Outline of Final Research Achievements

Following the ingestion of contaminated food or water, enterohemorrahgic Escherichia coli (EHEC) enters the gastrointestinal tract and is released into the intestine. It is important for estimation of pathogenicity and host immuno resistance of EHEC under absolute anaerobic conditions. Thus, we determined growth rate, production of Shiga toxins, resistance against reactive oxygen species, expression of virulence factors and drug resistance in EHEC under absolute anaerobic conditions using anaerobic chamber.

Free Research Field

病原細菌学