2015 Fiscal Year Final Research Report
Regulation of antivirus innate immunity by stress granules
| Project/Area Number |
26670222
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
HIGUCHI Masaya
TAKAHASHI Masahiko
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | stress granules / HTLV-1 / Tax / USP10 / G3BP1 |
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| Outline of Final Research Achievements |
USP10 is a component of stress granules. We established systemic USP10-knockout (KO) mice. USP10-KO mice developed bone marrow failure and severe anemia. Bone marrow failure in these USP10-KO mice was associated with reductions of hematopoietic stem cells（HSCs). Such USP10-KO HSCs exhibited enhanced apoptosis. These results suggest that USP10 is essential for hematopoiesis and functions by inhibiting apoptosis of HSCs, thereby regulating anti-viral immunity.
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| Free Research Field |
ウイルス学
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