2015 Fiscal Year Final Research Report
Platelets convert peripheral blood circulating monocytes to regulatory cells via immunoglobulin G and activating-type Fcg receptors.
| Project/Area Number |
26670230
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 抗炎症 / Fcレセプター / 抑制シグナル / IgG / IL-10 |
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| Outline of Final Research Achievements |
Augmented production of an immunoregulatory cytokine IL-10 with a concomitant reduction of proinflammatory cytokines in macrophages in vitro is attained by doubly stimulating the cells with a TLR ligand and IgG immune complexes, a response known as that of regulatory macrophages. However, it has not been explored sufficiently how such a regulatory response occurs in more physiologic settings. We showed that IgG-opsonized platelets convert human peripheral blood circulating monocytes to IL-10-producing regulatory monocytes in vitro and in vivo. This novel way of enhancing IL-10 was mediated by activating-type Fc receptor FcγRIIA. A therapeutic preparation of human polyclonal IgG (or IVIG) was found to react to platelets via the Fab portion, thereby converting circulating monocytes to regulatory cells. These findings indicate that the IgG-bound platelet-induced conversion provides a novel mechanism for homeostatic generation of regulatory monocytes.
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| Free Research Field |
医歯薬学（免疫学）
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