Establishment of murine model of autoimmune diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670232
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: National Center for Global Health and Medicine
• Principal Investigator: Miyadera Hiroko 国立研究開発法人国立国際医療研究センター, その他部局等, その他 (40361464)
• Research Collaborator: Okamura Tadashi 国立研究開発法人国立国際医療研究センター, 研究所, 室長 (00333790) ; Nakano Kenta 国立研究開発法人国立国際医療研究センター, 研究所, 技術職員 ; Takanashi Rieko 国立研究開発法人国立国際医療研究センター, 研究所, 技術職員 ; Okabe Yuki 国立研究開発法人国立国際医療研究センター, その他部局等, 技術補佐員
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 主要組織適合性抗原 / 自己免疫疾患 / ヒト白血球抗原

Outline of Final Research Achievements

Susceptibility to autoimmune diseases varies greatly among individuals. It has been known that various environmental and genetic factors contribute to susceptibility to autoimmune diseases. For certain autoimmune diseases, genes that encode human leukocyte antigens (HLA) is the strongest susceptibility loci, however, underlying mechanisms remain elusive. In this study, we have studied mechanism of autoimmune diseases by modifying the genes that encode major histocompatibility complex (MHC) of mouse, which is analogous to human HLA, to understand potential roles of HLA/MHC class II in the development of autoimmunity.

Free Research Field

免疫遺伝学、生化学