2015 Fiscal Year Final Research Report
Contribution of imperfect elimination of self-reactive T cells in the thymus to tumor immune surveillance
| Project/Area Number |
26670234
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Keywords | 癌免疫 / 自己免疫 / T細胞 / 胸腺 |
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| Outline of Final Research Achievements |
Immune system efficiently responses to various pathogens and tumors as non-self, but not against self-tissues. T lymphocytes (T cells) play a pivotal role on such discrimination between self and no-self. Epithelial cells in the thymic medulla (mTECs) eliminate self-tissue reactive T cells and also can delete T cells responsive to tumors in the thymus, thereby playing critical roles on discrimination between self and non-self by T cells. In this study, we investigated how fine tuning of the mTEC function contributes to the self- and non-self discrimination. We found that a negative feedback regulation of mTEC function ensures efficient immune responses to tumors. This study would provide some important information regarding tumor immune surveillance and contributes to developing efficient tumor immune therapies.
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| Free Research Field |
分子免疫学
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