• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2015 Fiscal Year Final Research Report

Development of innovative and ultimate strategies for the treatment of cerebral vasospams with thrombin receptor as a therapeutic target

Research Project

  • PDF
Project/Area Number 26670271
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied pharmacology
Research InstitutionKagawa University

Principal Investigator

Hirano Katsuya  香川大学, 医学部, 教授 (80291516)

Co-Investigator(Kenkyū-buntansha) HIRANO Mayumi  九州大学, 大学院医学研究院, 助教 (80336031)
Co-Investigator(Renkei-kenkyūsha) Kobayashi Sei  山口大学, 大学院医学研究科, 教授 (80225515)
Project Period (FY) 2014-04-01 – 2016-03-31
Keywordsトロンビン / 受容体 / 脱感作障害 / 内皮バリアー機能 / ミオシン軽鎖リン酸化 / 細胞内カルシウムシグナル / 蛋白質リン酸化 / 活性酸素
Outline of Final Research Achievements

Cerebral vasospasm is one of critical complications that develop after subarachnoid hemorrhage and influence vital and neurologic prognosis of the patients. The present study aims to develop innovative and ultimate strategies for the treatment of cerebral vasospasm with thrombin receptor as a therapeutic target, based on the understanding of the central mechanism of pathogenesis of vasospasm. As a result, the present research elucidated the mechanisms underlying (1) impairment of desensitization of thrombin receptor PAR1, (2) thrombin-induced endothelial barrier disruption and (3) thrombin-induced store-operated calcium influx. All these aspects play a critical role for the development of cerebral vasospasm. The findings of the present study therefore consolidated the basis for the development of a novel therapeutic strategy with PAR1 as a therapeutic target for the prevention and treatment of cerebral vasospasm.

Free Research Field

分子血管病態学、細胞内シグナル伝達、循環生理学

URL: 

Published: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi