Elucidation of the mechanism for itch induction by using a novel mouse model of atopic skin inflammation

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670287
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pain science
• Research Institution: Kyushu University
• Principal Investigator: Fukui Yoshinori 九州大学, 生体防御医学研究所, 教授 (60243961)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: シグナル伝達 / 生体分子 / 細胞・組織

Outline of Final Research Achievements

We have developed a novel mouse model that spontaneously causes atopic skin inflammation with severe scratching behavior. The majority of infiltrating cells were CD4+ T cells, and they produced a large amount of IL-31 upon stimulation. By crossing these mice with mice lacking oncostatin M receptor, we have shown that IL-31 signaling plays a key role in the disease development. In addition, we have identified a molecule critical for IL-31 production by CD4+ T cells.

Free Research Field

免疫細胞生物学