Central neuronal circuit underlying odor-induced analgesia

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670290
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pain science
• Research Institution: Kagoshima University
• Principal Investigator: Kashiwadani Hideki 鹿児島大学, 医歯学域医学系, 講師 (70328376)
• Co-Investigator(Renkei-kenkyūsha): KUWAKI TOMOYUKI 鹿児島大学, 医歯学域医学系, 教授 (80205260)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 鎮痛 / 匂い

Outline of Final Research Achievements

To assess whether the olfactory input mediates odorant-X-induced analgesia, we　examine the analgesia in olfactory deprived mouse. The formalin test and the　hot plate test revealed that the analgesic effects were not observed in olfactory deprived mouse, indicating that the olfactory input evoked by the odorant-X is necessary for the analgesia. Next, we examine the duration of the analgesic effects. The results indicated that the analgesic effects lasted at least 5 minutes after the odorant-X exposure. Furthermore, we examined the contribution of intrinsic opioid system to the analgesic effects, and found that the intrinsic analgesic system including mu-opioid receptors mediates the odorant X-induced analgesia in mice.

Free Research Field

感覚生理学