2016 Fiscal Year Annual Research Report
A challenge of real-time visualization of four-dimensional dose distributions on morphological images for intracavitary brachytherapy using a mobile gamma camera
| Project/Area Number |
26670301
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| Research Institution | Kyushu University |
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Principal Investigator |
有村 秀孝 九州大学, 医学研究院, 教授 (20287353)
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| Co-Investigator(Kenkyū-buntansha) |
中村 和正 九州大学, 大学病院, 准教授 (20284507) [Withdrawn]
藤淵 俊王 九州大学, 医学研究院, 准教授 (20375843)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | brachytherapy / portable camera / seed locations |
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| Outline of Annual Research Achievements |
Currently, we do not have any approaches to estimate the displacements of applicator, source, tumor, and organs at risk (OAR), and to monitor in-vivo dose distributions in real time for intracavitary brachytherapy. This is a crucial problem from the quality assurance point of view in the brachytherapy. Our purpose is to develop a dynamic adaptive brachytherapy system for real-time visualization of in-vivo locations of an applicator, 192Ir source, tumor, OAR, and dose distributions for intracavitary brachytherapy using a pixel-based portable radiation camera. We developed an approach to correct the source dwelling positions and times based on those determined on treatment plans.
Furthermore, we investigated whether in-room computed tomography (CT)-based adaptive treatment planning (ATP) is robust against interfractional location variations, namely, interfractional organ motions and/or applicator displacements, in 3D intracavitary brachytherapy (ICBT) for uterine cervical cancer. The results of this study suggest that the interfractional location variations give smaller impacts on the planning evaluation indices in 3D ATP than in 2D ATP. Therefore, the 3D plans with ATP are expected to be robust against interfractional location variations in each treatment fraction.
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