Cryo-immunology; booster effects of cryotherapy on the anti-tumor immune response

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670305
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital
• Principal Investigator: Saito Hiroya 医療法人徳洲会札幌東徳洲会病院付属臨床研究センター, がん研究部, 副部門長 (80524769)
• Research Collaborator: Nabeel Bardeesy Massachusetts General Hospital Cancer Center, Associate Professor
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Cryotherapy / IVR / がん

Outline of Final Research Achievements

Cryotherapy (also called cryosurgery) is a treatment that uses extremely cold temperature to freeze and destroy cancer tissue. Although mainly employed in cases of prostate cancer, the therapeutic option can be used to treat a number of different types of cancer. Curiously, distant and untreated sites of disease can also be regressed after freezing a primary lesion, suggesting cryotherapy may stimulate an anti-tumor immune response. Given the tremendous potential of the local therapy that could also have systemic benefits, we sought to validate the ability of cryotherapy to stimulate a tumor recognition using allograft mouse pancreatic cancer system as a pre-clinical model. The tumor bearing animals treated by cryotherapy decreased growth of either primary or secondary tumor (an imaginary metastasis) relative to the controls. Cryotherapy offers an option for treating cancers that do not respond to standard treatments, and more studies are needed to determine the long-term effects.

Free Research Field

IVR、がん