Use of human serum albumin as the measure of human body redox state might provide a new index of risk for lifestyle-related diseases

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670312
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Nagoya University
• Principal Investigator: Kondo Takaaki 名古屋大学, 医学(系)研究科(研究院), 教授 (00195900)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 血清アルブミン / redox / 動脈硬化 / 腎機能

Outline of Final Research Achievements

Human serum albumin takes either reduced (HMA) or oxidized form (HNA) in the human body.In this study, the fraction of HMA was examined for its association with the carotid intima-media thickness as atherosclerosis status, and eGFR as kidney function among about 300 healthy middle-aged and elderly persons. Results demonstrated reduced whole body state, as compared with oxidized state,is associated with decreased risk for atherosclerosis and favorable kidney function.

Free Research Field

公衆衛生学