2014 Fiscal Year Final Research Report
Epidemiological study of prevention biomarker for mood and anxiety disorder by CE/MS based metabolimics
| Project/Area Number |
26670319
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Epidemiology and preventive medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HIRAYAMA Akiyoshi 慶應義塾大学, 政策・メディア研究科, 特任助教 (00572405)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Tomonori 慶應義塾大学, 医学部, 教授 (00324567)
SOGA Tomoyoshi 慶應義塾大学, 環境情報学部, 教授 (60338217)
TOMITA Masaru 慶應義塾大学, 環境情報学部, 教授 (60227626)
SUGIMOTO Masahiro 慶應義塾大学, 政策・メディア研究科, 特任准教授 (30458963)
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| Research Collaborator |
KURIHARA Ayako 慶應義塾大学, 医学部, 助教
HARADA Sei 慶應義塾大学, 医学部, 助教
ISHIKAWA Takamasa 慶應義塾大学, 政策・メディア研究科, 特任助教
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Keywords | バイオマーカー / 代謝プロファイリング / 疫学 / 気分・不安障害 / 睡眠 |
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| Outline of Final Research Achievements |
Mood and anxiety disorder is important issue for population health, and development of effective screening method is sought-after. We compared metabolic profiling of plasma between high- and low- anxiety groups defined by K-6 score in a baseline survey of a population-based cohort study with CE/MS method. Out of 115 metabolites, 5 metabolites for male and 6 for female were significantly related to high K-6 score. I addition, metabolic profiling was compared between insomnia and normal sleep evaluated by Athens Insomnia Scale, but no significant result was observed. Further follow-up as well as detailed pathway analysis are to be done to elucidate causality.
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| Free Research Field |
疫学、予防医学
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