Plasma Na natriuretic peptide is increased risk of carotid atherosclerosis in a Japanese urban population

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670320
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: KOKUBO YOSHIHIRO 国立研究開発法人国立循環器病研究センター, 病院, 医長 (20393217)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 潜在性心不全 / 頸動脈エコー検査 / 疫学研究

Outline of Final Research Achievements

A total of 3239 participants (30-84 years old) were measured the plasma hANP (human atrial natriuretic peptide) and BNP (Brain natriuretic peptide) levels in the Suita Study. We defined hANP 43 pg/mL or more levels as high hANP and BNP 100 pg/mL or more levels as high BNP. Compared with BNP <100 pg/mL, relative risk (95% confidence intervals) of maximum intimal medial thickness 1.7 mm or more levels in BNP 100 pg/mL or more levels was 1.28 (1.01 to 1.61) by adjusting for age and sex, and 1.27 (1.01 to 1.60) by adjusting for age, sex, smoking, drinking, hypertension, hypercholesterolemia, diabetes mellitus, and body mass index. However, there is no association between hANP and internal medial thickness.

Free Research Field

予防医学