Animal model for cholangiocarcinoma associated with offset printing process

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670329
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hygiene and public health
• Research Institution: Tokyo University of Science
• Principal Investigator: Ichihara Gaku 東京理科大学, 薬学部薬学科, 教授 (90252238)
• Co-Investigator(Renkei-kenkyūsha): Shinya Toyokuni 名古屋大学, 大学院医学系研究科, 教授 (90252460)
• Research Collaborator: Zhang Lingyi 東京理科大学, 薬学部, ポストドクトラルフェロー ; Zhang Xiao 名古屋大学, 大学院医学系研究科 ; Zong Cai 東京理科大学, 薬学部, ポストドクトラルフェロー ; Sugie Shigeyuki 朝日大学, 歯学部, 教授
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 胆管がんの原因物質

Outline of Final Research Achievements

Although serial cases of cholangiocarcinoma found in an offset printing factory suggest that 1,2-dichloropropane (DCP) is the causative agent for them, the past bioassay studies did not show cholangiocarcinoma. The present study showed difficulty in explaining the species difference in susceptibility to DCP by distribution of glutathione S-transferase. Moreover the study is the first to demonstrate that exposure to DCP induce proliferation and apoptosis of cholangiocytes, as well as contribution of P450 to such effects. The present study strongly indicates that DCP is the causative agent for cholangiocarcinoma.

Free Research Field

環境労働衛生学