2015 Fiscal Year Final Research Report
Development of the molecular targeting cancer prevention for diabetics by the activation of TRAIL pathway.
| Project/Area Number |
26670336
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene and public health
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | がん / 糖尿病 / 予防 / TRAIL |
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| Outline of Final Research Achievements |
TRAIL is a cytokine which can induce apoptosis against cancer cells and contribute to cancer prevention. We examined whether the decline of immunity due to diabetes resulted in the down-regulation of TRAIL expression causing subsequent carcinogenesis.
We compared the expression of TRAIL mRNA of the organ samples from a type 2 diabetes model of the rat and mouse with those from normal animals. As the results, TRAIL expressions of cDNA samples derived from large intestine and pancreas of the diabetes model animals were lower than those from normal animals. On the other hand, a diabetes therapeutic drug metformin enhanced the TRAIL sensitivity for several human pancreatic cancer cells.
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| Free Research Field |
がん予防
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