Molecular mechanism of cardiorenal syndrome -search of useful diagnostic markers in forensic medicine-

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670358
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Legal medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Kimura Akihiko 和歌山県立医科大学, 医学部, 准教授 (60136611)
• Co-Investigator(Kenkyū-buntansha): KONO TOSHIKAZU 和歌山県立医科大学, 医学部, 教授 (70251923) ; ISHIDA YUKO 和歌山県立医科大学, 医学部, 講師 (10364077) ; NOSAKA MIZUHO 和歌山県立医科大学, 医学部, 助教 (00244731)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 心腎連関 / IFN-gamma / ANP / apoptosis

Outline of Final Research Achievements

In this study, we examined the pathogenic role of IFN-gamma in type 1 cardiorenal syndrome in mouse model of transverse aortic constriction (TAC). Severe TAC induced renal injury in IFN-gamma-KO mouse but not in wild-type (WT) mouse, suggesting that IFN-gamma plays a protective role in TAC-induced renal injury (type 1 cardiorenal syndrome). Severe TAC enhanced intracardiac ANP gene expression in WT mice, which was significantly reduced in IFN-gamma-KO mice. ANP infusion significantly attenuated severe TAC-induced renal injury in IFN-gamma-KO mice, indicating that IFN-gamma plays a protective role in type 1 cardiorenal syndrome through enhance of ANP gene expression.

Free Research Field

法医学