2016 Fiscal Year Final Research Report
Development of an allergy diagnostic system for kampo medicine using eastern blot technique
| Project/Area Number |
26670373
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Daiichi University, College of Pharmaceutical Sciences (2016)
Nagasaki International University (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 漢方薬 / 副作用 / アレルギー / 間質性肺炎 / 下痢 / イースタンブロット法 / フラボノイド配糖体 / センノシド |
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| Outline of Final Research Achievements |
We focused on various flavonoids among major components of kampo medicine with adverse reaction reports and developed highly sensitive eastern blotting method for liquiritin and hesperidin. The flavonoid glycoside is metabolized by intestinal bacteria and undergoes a conjugation reaction in the liver, and it is thought that various adverse reaction reports may be caused by the conjugated metabolite.
In addition, we assumed the cause of interstitial pneumonia as narcissin and then worked on the development of eastern blotting method which can detect with high sensitivity.
Senosides A and B in kampo medicines were analyzed for the purpose of reducing the adverse reaction reports of kampo medicine, and examined as to whether it is possible to prevent adverse reaction reports of diarrhea from sennoside A and B contents per tablet or per package.
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| Free Research Field |
生薬学
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