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2016 Fiscal Year Final Research Report

New method for diagnosis for colon cancers by using stem cell as a target

Research Project

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Project/Area Number 26670377
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionThe University of Tokyo

Principal Investigator

Shibasaki Yoshikazu  東京大学, 先端科学技術研究センター, 特任教授 (80196419)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsインビボイメージング / 幹細胞 / 大腸がん / EGFファミリー
Outline of Final Research Achievements

Epiregulin (EPR) is a member of EGF family ligands and exert numerous cellular functions including stem cell stimulation. EPR is synthesized as a membrane-anchored protein (pro-EPR) and then proteolytically cleaved to yield a soluble form of EPR. While it is expressed at relatively low levels in most adult tissues, EPR is overexpressed in human colon, breast, and other cancers. We developed several anti-EPR monoclonal antibodies that specifically recognize human EPR, but not other EGF family ligands. Anti-EPR antibody is internalized into epiregulin expressing cancer cells. Using this system, we developed a mouse in vivo imaging system for epiregulin producing tumor. Our results suggest that anti-EPR antibodies represent valuable tools for medical imaging and for delivering agents for the treatment of cancers

Free Research Field

細胞生物学

URL: 

Published: 2018-03-22  

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