2015 Fiscal Year Final Research Report
Development of a new Iodine contrast agent excreted into bile and urine based on the transporter selectivity
| Project/Area Number |
26670388
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
JUTABHA Promsuk 獨協医科大学, 医学部, 助教 (90541748)
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| Co-Investigator(Renkei-kenkyūsha) |
ANZAI Naohiko 千葉大学, 大学院医学研究院, 教授 (70276054)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 造影剤 |
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| Outline of Final Research Achievements |
We designed two candidates of a new iodine-containing contrast agent by giving a side chain to Iohexol. We named them as I-A, and I-B. They were applied to chemical transport experiment. I-A significantly inhibited the substrate uptake from OATP1B3 and OATP2B1. I-B strongly inhibited the substrate uptake from OATP1B1, 1B3, and 2B1. Iohexol did not inhibit the substrate uptake from any OATP transporters. Animal experiment revealed bile duct excretion of I-A. We confirmed if the density of I-A is less than 125mg/ml, it can be administered to mice without any obvious side effects. However we could not identify the bile duct excretion of I-B. Because of the heigh viscosity of I-B dissolved into water, mice could not survive after the administration of I-B. We successfully gave an existing Iodine contrast agent a new function to accumulate in cells through hepatocyte specific transporters. And one of them was excreted into bile.
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| Free Research Field |
肝臓病学
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