Cardiac magnetic resonance imaging-guided evaluation of right ventricular dyssynchrony and cardiac resynchronization therapy for severe right ventricular heart failure

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670392
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: 独立行政法人国立病院機構高崎総合医療センター(臨床研究部) (2016); Gunma University (2014-2015)
• Principal Investigator: Ota Masaki 独立行政法人国立病院機構高崎総合医療センター(臨床研究部), 臨床研究部, 循環器内科 医師 (10719876)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 右心不全 / 心臓再同期療法 / 心臓MRI画像

Outline of Final Research Achievements

Right ventricular (RV) mechanical dyssynchrony is proposed as a desirable therapeutic target in patients with right bundle branch block (RBBB) or RV apical pacing complicated with RV heart failure and can be visualized by transthoracic echocardiography or electroanatomical mapping that reveals a marked conduction delay of the RV free wall compared to the septal wall. Right-sided cardiac resynchronization therapy (R-CRT) by application of additional pacing at the RV free wall is effective for treatment of RV heart failure refractory to medical therapy in patients with RV dyssynchrony. To perform R-CRT by using standard CRT equipped with three ports only, one can connect the RV apical lead to the RV port to keep ventricular sensing stable, and connected the other two leads at the RV free wall and LV to LV port via the Y-connector.

Free Research Field

循環器内科