2015 Fiscal Year Final Research Report
Elucidation of functional role of gut microbiota in heart failure
| Project/Area Number |
26670395
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOMURO Issei 東京大学, 医学部附属病院, 教授 (30260483)
KAMO Takehiro 東京大学, 医学部附属病院, 特任臨床医 (10722556)
HONDA Kenya 慶應義塾大学, 医学部, 教授 (60334231)
MORITA Hidetoshi 岡山大学, 農学部, 教授 (70257294)
HATTORI Masahira 早稲田大学, 理工学術院, 教授 (70175537)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 心不全 / 腸内細菌叢 |
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| Outline of Final Research Achievements |
To investigate whether gut microbiota in patients with heart failure (HF) is altered, we compared the gut microbiota of HF patients with that of healthy volunteers. Analysis of the bacterial 16S ribosomal RNA gene provided evidence that the number of operational taxonomic units (OTUs) was not different. However, both unweighted and weighted UniFrac analyses showed a significant difference in gut microbiota samples from HF patients and healthy controls. Furthermore, it also showed a significant difference in gut microbiota samples form younger HF patients and older HF patients. These results suggest that gut microbiota is altered in HF patients, and is also influenced by aging, supporting the concept “Heart-Gut axis” that hemodynamic change in HF may induce dysbiosis, and that it may be involved in the progression of HF.
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| Free Research Field |
分子心臓学
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