2014 Fiscal Year Final Research Report
Regulation of differentiation, regeneration, and homeostasis via signaling-epigenome interaction
| Project/Area Number |
26670401
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
JUN YAMASHITA 京都大学, iPS細胞研究所, 教授 (50335288)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Keywords | 多能性幹細胞 / 分化 / エピジェネティクス / 液性因子 |
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| Outline of Final Research Achievements |
Purpose of this study is development of novel manipulating methods of epigenome through identification of signaling molecules being involved in epigenetic regulation.
We identified a humoral factor that regulate differentiation velocity in early differentiation stage of pluripotent stem cells through epigenetic silencing of pluripotent genes.Now we are investigating other physiological functions of the gene than differentiation through epigenetic regulation.
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| Free Research Field |
幹細胞生物学
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