2016 Fiscal Year Final Research Report
The role of Cavin family proteins in cardiovascular disease
| Project/Area Number |
26670407
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Ueyama Tomomi 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (80379388)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | カベオラ / Cavin family |
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| Outline of Final Research Achievements |
PTRF/Cavin-1 deficiency in mice causes loss of caveolae in cardiomyocytes, impaired cardiac function accompanying cardiomyocyte hypertrophy and interstitial fibrosis. MURC deficiency in mice attenuates cardiac hypertrophy induced by α1-adrenergic receptor stimulation and pulmonary hypertension induced by hypoxia. MURC deficiency, on the other hand, exacerbated abdominal aortic aneurysm (AAA) in mice. These results reveals that PTRF/Cavin-1 regulates cardiac function, and that MURC is involved in the development of cardiac hypertrophy, pulmonary hypertension, and AAA.
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| Free Research Field |
医歯薬学
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