2015 Fiscal Year Final Research Report
Induction of tolerance in the airways by extracellular ATP
| Project/Area Number |
26670420
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kitasato University (2015)
Keio University (2014) |
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Principal Investigator |
Suzuki Yusuke 北里大学, 北里研究所病院, 部長(医師) (80306696)
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| Co-Investigator(Renkei-kenkyūsha) |
KUBO Akiharu 慶應義塾大学, 医学部, 専任講師 (70335256)
KAWASAKI Hiroshi 慶應義塾大学, 医学部, 特任助教 (70445344)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 免疫寛容 |
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| Outline of Final Research Achievements |
Our animal experiments indicated amelioration of allergic airway inflammation after skin injury, which was opposite to commonsense. Thus we hypothesized that skin injury induced an allergy-protecting factor.
We assumed the factor would be ATP and administrated ATP directly on animal skin. However, it turned out to be ineffective. We are seeking another candidate factor by analyzing injured skin tissue with DNA microarray.
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| Free Research Field |
アレルギー
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