Investigation of the renal injury mechanism induced by renal congestion.

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670424
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Tohoku University
• Principal Investigator: MORI TAKEFUMI 東北大学, 医学(系)研究科(研究院), 准教授 (40375001)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 腎臓 / 腎機能 / 心腎症候群 / うっ血 / 腎障害 / 利尿薬 / 腎臓間質静水圧

Outline of Final Research Achievements

We investigated the effect of renal congestion on the renal function and renal injury in rats. Renal venous congestion decreased urinary flow and glomerular filtration ratio. These results indicate that the renal congestion could cause the further accumulation of body fluid, and form a vicious cycle. Renal congestion also induced renal interstitial fibrosis, tubular injury and inflammation in the chronic phase. The renal interstitial hydrostatic pressure could contribute to these renal injury. Diuretics attenuated renal injury induced by renal congestion in some part.

Free Research Field

腎臓生理学