Aging-related alterations in the control of glomerular hemodynamics: pathophysiological significance in the aging kidney.

2016 Fiscal Year Final Research Report

• Project/Area Number: 26670434
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Kindai University
• Principal Investigator: ARIMA Shuji 近畿大学, 医学部, 教授 (60323010)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 輸出入細動脈 / 腎硬化症 / 酸化ストレス / オートファジー / 加齢

Outline of Final Research Achievements

Using malignant hypertension model rats (M-SHRSP) we found that activations of endoplasmic reticulum stress (ERS) and apoptotic pathway but not autophagy are involved in the pathophysiology of hypertensive renal damage. We also found that antihypertensive therapy improve renal damage by downregulating ERS pathway, though it upregulats autophagy pathways. These findings raise a possibility that ERS and autophagy could be a new therapeutic target for hypertensive renal disease, especially malignant nephrosclerosis.
On the other hand, we could not obtain any successful results in the series of physiological study. We found neither age-related alterations in the control of glomerular hemodynamics nor in the vascular reactivity of renal arterioles. In addition, we could not establish a culture system of vascular smooth muscle cells and endothelial cells of renal arterioles to study their detail cellular mechanisms.

Free Research Field

医歯薬学　腎臓内科学