2014 Fiscal Year Final Research Report
Anti-atherosclerotic properties of radical-containing nanoparticle
| Project/Area Number |
26670448
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUZAKA Takashi 筑波大学, 医学医療系, 准教授 (70400679)
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| Project Period (FY) |
2014-04-01 – 2015-03-31
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| Keywords | ナノメディシン / 動脈硬化 |
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| Outline of Final Research Achievements |
pH-insensitive radical-containing nanoparticle (RNP-O) is a newly synthesized nanoparticle intended to treat oxidative stress related disease. We assessed the effects of RNP-O on atherosclerosis. RNP-O treatment significantly decreased the atherosclerotic lesion area in western diet-fed LDLRKO mice. RNP-O treatment also caused the change of microbiota. RNP-O can be a novel anti-atherogenic candidate through regulation of microbiota.
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| Free Research Field |
代謝内分泌学
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