2015 Fiscal Year Final Research Report
Discovery of patients with hyper-HDL cholesterolemia possibly due to endothelial lipase (EL) and analysis of EL phisiological function
Project/Area Number |
26670450
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
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Research Institution | Osaka University |
Principal Investigator |
Yamashita Shizuya 大阪大学, 医学(系)研究科(研究院), 特任教授 (60243242)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Keywords | 高HDL血症 / 内皮リパーゼ |
Outline of Final Research Achievements |
We found a subject who showed a marked hyper HDL-cholesterolemia with intima-media complex thickening of carotid artery, possibly due to extreme low plasma activity and concentration of endothelial lipase. HPLC analysis also showed that HDL particle was increased in diameter and contains rich TG. However, exon sequence analysis exhibited that significant mutations have not been found in the exon and exon-intron boundaries of EL. Therefore, we reexamined EL mass, but it is almost within normal limits. EL concentration have been shown to be influenced by various factors including stock conditions. In this case, EL concentration tends to be low, but its values often vary. Hyper HDL-cholesterolemia is considered to be due to mutations in upstream regulatory regions of EL genes or abnormalities of proteins which can modulate EL activity.
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Free Research Field |
動脈硬化、脂質代謝、循環器内科
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