Roles of trk-fused gene product protein

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670451
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Hiroshima University
• Principal Investigator: Asano Tomoichiro 広島大学, 医歯薬保健学研究院(医), 教授 (70242063)
• Co-Investigator(Renkei-kenkyūsha): NAKATSU YUSUKE 広島大学, 大学院医歯薬保健学研究院, 講師 (20452584) ; FUKUSHIMA TOSHIAKI 広島大学, 大学院医歯薬保健学研究院, 助教 (70543552) ; SAKODA HIDEYUKI 宮崎大学, 医学部附属病院, 講師 (50376464) ; FUJISHIRO MIDORI 東京大学, 医学部附属病院, 助教 (50420211) ; HONDA HIROAKI 広島大学, 原爆放射線医科学研究所, 教授 (40245064)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 代謝 / 糖尿病 / ＴＦＧ / インスリン

Outline of Final Research Achievements

We identified TFG asa a protein which binds to PTEN. In fact, overexpression of TFG in the cultured cells induced an increased intracellular content of PIP3. In addition, recent reports revealed the TFG gene to be responsible for the occurence of nerurogenerative diseases. Thus, we generated tissue- specific TFG KO mice, to elucidate the roles of TFG on metabolic as well as neural functions. We found the reduced mass of pancreatic beta cells and impaired glucose-induced insulin secretion in the beta cell specific TFG KO mice. Therefore, TFG plays a critical role on not only the neural function, but also glucose metabolism via the regulation of insulin secretion. At present, we are trying to reveal the detailed machanisms underlying TFG-induced regulation of insulin secretion.

Free Research Field

代謝学