Regenerative therapy for metabolic diseases based on chemical direct reprogramming

2014 Fiscal Year Final Research Report

• Project/Area Number: 26670452
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: OSAM Mazda 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00271164)
• Co-Investigator(Renkei-kenkyūsha): KAWAHITO Utaka 京都府立医科大学, 医学研究科, 准教授 (50336731)
• Research Collaborator: KISHIDA Tsunao 京都府立医科大学, 准教授 (00370205) ; OHGITANI Eriko 京都府立医科大学, 医学研究科, 助教 (80300820) ; WATANABE Eri 京都府立医科大学, 助教 (20433253) ; SHIN-YA Masaharu 京都府立医科大学, プロジェクト研究員 (10405277) ; KIYOSHI Kazunari 京都大学, 工学研究科, 教授 (90201285) ; KITABATAKE Yasuji 大阪大学, 医学系研究科, 助教 (80506494)
• Project Period (FY): 2014-04-01 – 2015-03-31
• Keywords: 糖脂質代謝

Outline of Final Research Achievements

Brown adipocytes (BAs) expend energy as heat. Recently we succeeded in directly inducing human brown adipocytes from the fibroblasts. Here we aimed at establishing a direct reprogramming procedure to obtain brown adipocytes from fibroblasts by means of small chemical compounds. We established a high-sensitivity and high-throughput screening system and screened a chemical library. As result we found some candidates that satisfied screening criteria. The present study may contribute to understanding of differentiation of brown adipocytes, while it may also lead to novel regenerative therapy for metabolic diseases.

Free Research Field

再生医学