2015 Fiscal Year Final Research Report
Maturation Process of beta cells using New-timer mouse
| Project/Area Number |
26670454
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Miyatsuka Takeshi 順天堂大学, 医学部, 准教授 (60622363)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 膵β細胞 / インスリン / 発生分化 |
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| Outline of Final Research Achievements |
We generated “Insulin-new-Timer mouse” and investigated the presence of “new-born-beta cells” and “matured-beta cells” by observing “green-cells” and “yellow cells”, respectively in pancreas isolated from the mice at P 0.5. In the pancreas, green cells locate around ducts and yellow cells form islet-like structure and locate far away from the ducts. These data suggest as expected before, beta cells differentiate from endocrine precursor cells around the ducts and move from ducts to inter-lobes of exocrine cells and form islets. On the other hand, green cells are also locate around islets and in the islets, green cells locates around endothelial cells. These data unexpectedly suggest that some beta cells are formed in the islets, and for this formation, signals from endothelial cells may be essential.
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| Free Research Field |
代謝学
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