The clarification of pathogenesis and medical treatment of functional pituitary adenoma using iPS cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 26670459
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Kobe University
• Principal Investigator: Takahashi Yutaka 神戸大学, 医学(系)研究科(研究院), 准教授 (70301281)
• Co-Investigator(Kenkyū-buntansha): FUKUOKA Hidenori 神戸大学, 医学部附属病院, 助教 (80622068)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Keywords: 下垂体 / 腫瘍 / 原因 / 疾患特異的iPS細胞

Outline of Final Research Achievements

To clarify the pathogenesis and medical treatment of functional pituitary adenoma, we have performed a comprehensive genetic analysis of the GH-producing pituitary adenoma. Regarding Cushing’s disease, we performed a microarray analysis and screened molecular targeted therapy using primary culture tumor cells. We have further established a protocol for the differentiation from human iPS cells into pituitary in vitro. We have published 15 English papers and 13 Japanese papers.

Free Research Field

内分泌学