2015 Fiscal Year Final Research Report
Elucidation of pancreatic beta-cell proliferation and differentiation mechanism by novel intestinal secretory protein IBCAP (betagenin).
| Project/Area Number |
26670462
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAZAKI YASUSHI 埼玉医科大学, 医学部, 教授 (80280733)
TOYOSHIMA HIDEO 埼玉医科大学, 医学部, 客員准教授 (20197966)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Keywords | 糖尿病 / 膵β細胞 |
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| Outline of Final Research Achievements |
Betagenin is another intestine-specific secretory protein with β-cell augmenting activity, identified in our laboratory. In the current study, we investigated putative β-cell transdifferentiational function of betagenin. First, betagenin synthetic peptide, based on the sequence of the purified secreted protein, stimulated the proliferation of MIN6 cells. In addition, we have results suggesting that betagenin may contribute to the induction of iPS cell differentiation to β-cells. Our findings indicate that betagenin have an activity to induce not only proliferation but also differentiation of β-cells. Betagenin may be used as a potent inducer for pancreatic β-cell regeneration.
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| Free Research Field |
代謝内分泌学
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